hapten-liganded protein - significado y definición. Qué es hapten-liganded protein
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Qué (quién) es hapten-liganded protein - definición

SMALL ANTIGENIC DETERMINANTS CAPABLE OF ELICITING AN IMMUNE RESPONSE ONLY WHEN COUPLED TO A CARRIER
Haptens; Haptene; Haptenic; Hapten inhibition; Hapten inhibitor

hapten         
['hapt?n]
¦ noun Physiology a small molecule which, when combined with a carrier protein, can elicit the production of antibodies.
Origin
1920s: from Gk haptein 'fasten'.
Hapten         
Haptens are small molecules that elicit an immune response only when attached to a large carrier such as a protein; the carrier may be one that also does not elicit an immune response by itself (in general, only large molecules, infectious agents, or insoluble foreign matter can elicit an immune response in the body).
Proteinprotein interaction         
  • The horseshoe shaped ribonuclease inhibitor (shown as wireframe) forms a protein–protein interaction with the ribonuclease protein. The contacts between the two proteins are shown as coloured patches.
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  • Principle of tandem affinity purification
  • Principles of yeast and mammalian two-hybrid systems
  • NMR structure of cytochrome C illustrating its dynamics in solution
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  • [[Text mining]] protocol.
PHYSICAL INTERACTIONS AND CONSTRUCTIONS BETWEEN MULTIPLE PROTEINS
List of protein interactions; Protein-protein interactions; Protein protein interaction; Protein interaction; Protein-protein interaction assays; Protein-protein interaction; Protein–protein interactions; Protein-protein interface; Protein protein interfaces
Proteinprotein interactions (PPIs) are physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by interactions that include electrostatic forces, hydrogen bonding and the hydrophobic effect. Many are physical contacts with molecular associations between chains that occur in a cell or in a living organism in a specific biomolecular context.

Wikipedia

Hapten

Haptens (derived from the Greek haptein, meaning “to fasten”) are small molecules that elicit an immune response only when attached to a large carrier such as a protein; the carrier may be one that also does not elicit an immune response by itself. The mechanisms of absence of immune response may vary and involve complex immunological interactions, but can include absent or insufficient co-stimulatory signals from antigen-presenting cells.

Haptens have been used to study allergic contact dermatitis (ACD) and the mechanisms of inflammatory bowel disease (IBD) to induce autoimmune-like responses.

The concept of haptens emerged from the work of Austrian immunologist Karl Landsteiner, who also pioneered the use of synthetic haptens to study immunochemical phenomena.